Impact Of Dapagliflozin Treatments On Cardiorenal Outcomes In Acutely Decompensated Heart Failure
HFSA ePoster Library. Charaya K. 09/10/21; 343856; 37
Kristina Charaya
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Abstract
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Introduction: Expanding the heart transplant donor pool with Hepatitis C positive donors has helped to offset the shortage of organs for patients with end stage heart failure in need of heart transplantation with post-transplant survival rates similar to patients receiving non hepatitis C positive donor hearts. Patients who are highly sensitized require more aggressive immunosuppression than non-sensitized patients and have worse outcomes. How degree of sensitization affects patients receiving Hep C positive donor hearts is unknown.
Hypothesis: There is an increased risk of death, rejection, or graft failure according to degree of sensitization on patients who received heart transplantation from Hepatitis C NAT positive donors.
Methods: A total of 831 patients were identified from the United Network for Organ Sharing (UNOS) registry who had received a heart transplant from a Hepatitis C positive donor from January 1, 2015 to October 17, 2019. These patients were distributed into four groups based on degree of sensitization using panel reactive antibody (PRA) percentage and were assessed for one year survival. The groups were defined as non sensitized (PRA of 0%), low degree of sensitization (0%-20%), intermediate degree of sensitization (21%-50%), and high degree of sensitization (>50%). Categorical variables were analyzed using chi-squared test. Wilcoxon-Mann-Whitney test was used to analyze all variables with non-normal distribution. Proportions were compared used Fischer’s exact test. All p-values <0.05 will be considered significant.
Results: Majority of the transplant recipients were not sensitized (72.8%), low degree of sensitization 10.6%, intermediate 8.4%, and high 8.2%. All baseline characteristics were distributed evenly between the four groups. There was no difference in one year survival when comparing the groups.
Conclusions: Highly sensitized patients should continue to be considered for hepatitis c donor hearts with overall favorable one year survival when compared to those patients who have no sensitization.
Hypothesis: There is an increased risk of death, rejection, or graft failure according to degree of sensitization on patients who received heart transplantation from Hepatitis C NAT positive donors.
Methods: A total of 831 patients were identified from the United Network for Organ Sharing (UNOS) registry who had received a heart transplant from a Hepatitis C positive donor from January 1, 2015 to October 17, 2019. These patients were distributed into four groups based on degree of sensitization using panel reactive antibody (PRA) percentage and were assessed for one year survival. The groups were defined as non sensitized (PRA of 0%), low degree of sensitization (0%-20%), intermediate degree of sensitization (21%-50%), and high degree of sensitization (>50%). Categorical variables were analyzed using chi-squared test. Wilcoxon-Mann-Whitney test was used to analyze all variables with non-normal distribution. Proportions were compared used Fischer’s exact test. All p-values <0.05 will be considered significant.
Results: Majority of the transplant recipients were not sensitized (72.8%), low degree of sensitization 10.6%, intermediate 8.4%, and high 8.2%. All baseline characteristics were distributed evenly between the four groups. There was no difference in one year survival when comparing the groups.
Conclusions: Highly sensitized patients should continue to be considered for hepatitis c donor hearts with overall favorable one year survival when compared to those patients who have no sensitization.
Introduction: Expanding the heart transplant donor pool with Hepatitis C positive donors has helped to offset the shortage of organs for patients with end stage heart failure in need of heart transplantation with post-transplant survival rates similar to patients receiving non hepatitis C positive donor hearts. Patients who are highly sensitized require more aggressive immunosuppression than non-sensitized patients and have worse outcomes. How degree of sensitization affects patients receiving Hep C positive donor hearts is unknown.
Hypothesis: There is an increased risk of death, rejection, or graft failure according to degree of sensitization on patients who received heart transplantation from Hepatitis C NAT positive donors.
Methods: A total of 831 patients were identified from the United Network for Organ Sharing (UNOS) registry who had received a heart transplant from a Hepatitis C positive donor from January 1, 2015 to October 17, 2019. These patients were distributed into four groups based on degree of sensitization using panel reactive antibody (PRA) percentage and were assessed for one year survival. The groups were defined as non sensitized (PRA of 0%), low degree of sensitization (0%-20%), intermediate degree of sensitization (21%-50%), and high degree of sensitization (>50%). Categorical variables were analyzed using chi-squared test. Wilcoxon-Mann-Whitney test was used to analyze all variables with non-normal distribution. Proportions were compared used Fischer’s exact test. All p-values <0.05 will be considered significant.
Results: Majority of the transplant recipients were not sensitized (72.8%), low degree of sensitization 10.6%, intermediate 8.4%, and high 8.2%. All baseline characteristics were distributed evenly between the four groups. There was no difference in one year survival when comparing the groups.
Conclusions: Highly sensitized patients should continue to be considered for hepatitis c donor hearts with overall favorable one year survival when compared to those patients who have no sensitization.
Hypothesis: There is an increased risk of death, rejection, or graft failure according to degree of sensitization on patients who received heart transplantation from Hepatitis C NAT positive donors.
Methods: A total of 831 patients were identified from the United Network for Organ Sharing (UNOS) registry who had received a heart transplant from a Hepatitis C positive donor from January 1, 2015 to October 17, 2019. These patients were distributed into four groups based on degree of sensitization using panel reactive antibody (PRA) percentage and were assessed for one year survival. The groups were defined as non sensitized (PRA of 0%), low degree of sensitization (0%-20%), intermediate degree of sensitization (21%-50%), and high degree of sensitization (>50%). Categorical variables were analyzed using chi-squared test. Wilcoxon-Mann-Whitney test was used to analyze all variables with non-normal distribution. Proportions were compared used Fischer’s exact test. All p-values <0.05 will be considered significant.
Results: Majority of the transplant recipients were not sensitized (72.8%), low degree of sensitization 10.6%, intermediate 8.4%, and high 8.2%. All baseline characteristics were distributed evenly between the four groups. There was no difference in one year survival when comparing the groups.
Conclusions: Highly sensitized patients should continue to be considered for hepatitis c donor hearts with overall favorable one year survival when compared to those patients who have no sensitization.
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