Reverse Remodeling With Neurohormonal Blockade Following Left Ventricular Assist Device Implantation
HFSA ePoster Library. Plazak M. 09/10/21; 343382; 157
Michael Plazak
REGULAR CONTENT
Login now to access Regular content available to all registered users.
Abstract
Discussion Forum (0)
Introduction: Left ventricular assist device (LVAD) implantation in older individuals are being increasingly performed over the last decade. Data on outcomes among older patients undergoing LVAD implantation is conflicting. While some studies suggest that patients >70 years of age have similar outcomes to younger patients, other studies suggest older patients have reduced survival.
Hypothesis: We hypothesize that clinical outcomes of LVAD implantation are less favorable with increasing age. We describe the characteristics and outcomes of patients receiving an LVAD at our center stratified by age. Methods: A retrospective, observational, descriptive study was conducted at our center. Patients who were admitted between January 2013 and July 2019 were divided into three groups—younger (aged < 65 years); senior (65-69 years); and older adult (aged ≥ 70 years). Group assignment was based on the age at the time of LVAD implantation. We compared the outcomes of the three groups using analysis of variance and chi-square tests. Results: 330 patients were included in the final analysis. The majority of patients were younger (74.2%, 245/330). Senior patients accounted for 16.4% (54/330) of the population, and 9.4% (31/330) were older adults. All variables (the total length of stay, the length of stay following LVAD implant implantation, the percentage of patients with readmissions at 30 days, and all-cause mortality at 1 year) were similar among the three age-stratified groups. Conclusions: Despite the commonly held notion that older patients do not fare well and tend to have a higher incidence of complications resulting in a longer length of stay and higher overall mortality, we found no difference in mortality at 1 year. Well-defined, prospective studies are needed to understand the impact of age and frailty on long-term outcomes.
Hypothesis: We hypothesize that clinical outcomes of LVAD implantation are less favorable with increasing age. We describe the characteristics and outcomes of patients receiving an LVAD at our center stratified by age. Methods: A retrospective, observational, descriptive study was conducted at our center. Patients who were admitted between January 2013 and July 2019 were divided into three groups—younger (aged < 65 years); senior (65-69 years); and older adult (aged ≥ 70 years). Group assignment was based on the age at the time of LVAD implantation. We compared the outcomes of the three groups using analysis of variance and chi-square tests. Results: 330 patients were included in the final analysis. The majority of patients were younger (74.2%, 245/330). Senior patients accounted for 16.4% (54/330) of the population, and 9.4% (31/330) were older adults. All variables (the total length of stay, the length of stay following LVAD implant implantation, the percentage of patients with readmissions at 30 days, and all-cause mortality at 1 year) were similar among the three age-stratified groups. Conclusions: Despite the commonly held notion that older patients do not fare well and tend to have a higher incidence of complications resulting in a longer length of stay and higher overall mortality, we found no difference in mortality at 1 year. Well-defined, prospective studies are needed to understand the impact of age and frailty on long-term outcomes.
| Total | Younger (aged <65 years) | Senior (65-69 years) | Older adults (aged ≥ 70 years) | P value | |
| N | 330 (100%) | 245 (74.2%) | 54 (16.4%) | 31 (9.4%) | |
| Total length of stay at index hospitalization | 48.10 ± 32.65 | 59.48 ± 41.05 | 49.42 ± 33.62 | 0.088 | |
| Length of stay post-LVAD | 28.76 ± 25.34 | 31.87 ± 31.47 | 32.29 ± 31.00 | 0.630 | |
| 30-da7 readmissions | 39.18% | 33.33% | 38.71% | 0.724 | |
| All-cause mortality rates at 1 year | 12.65% | 18.52% | 22.58% | 0.223 |
Introduction: Left ventricular assist device (LVAD) implantation in older individuals are being increasingly performed over the last decade. Data on outcomes among older patients undergoing LVAD implantation is conflicting. While some studies suggest that patients >70 years of age have similar outcomes to younger patients, other studies suggest older patients have reduced survival.
Hypothesis: We hypothesize that clinical outcomes of LVAD implantation are less favorable with increasing age. We describe the characteristics and outcomes of patients receiving an LVAD at our center stratified by age. Methods: A retrospective, observational, descriptive study was conducted at our center. Patients who were admitted between January 2013 and July 2019 were divided into three groups—younger (aged < 65 years); senior (65-69 years); and older adult (aged ≥ 70 years). Group assignment was based on the age at the time of LVAD implantation. We compared the outcomes of the three groups using analysis of variance and chi-square tests. Results: 330 patients were included in the final analysis. The majority of patients were younger (74.2%, 245/330). Senior patients accounted for 16.4% (54/330) of the population, and 9.4% (31/330) were older adults. All variables (the total length of stay, the length of stay following LVAD implant implantation, the percentage of patients with readmissions at 30 days, and all-cause mortality at 1 year) were similar among the three age-stratified groups. Conclusions: Despite the commonly held notion that older patients do not fare well and tend to have a higher incidence of complications resulting in a longer length of stay and higher overall mortality, we found no difference in mortality at 1 year. Well-defined, prospective studies are needed to understand the impact of age and frailty on long-term outcomes.
Hypothesis: We hypothesize that clinical outcomes of LVAD implantation are less favorable with increasing age. We describe the characteristics and outcomes of patients receiving an LVAD at our center stratified by age. Methods: A retrospective, observational, descriptive study was conducted at our center. Patients who were admitted between January 2013 and July 2019 were divided into three groups—younger (aged < 65 years); senior (65-69 years); and older adult (aged ≥ 70 years). Group assignment was based on the age at the time of LVAD implantation. We compared the outcomes of the three groups using analysis of variance and chi-square tests. Results: 330 patients were included in the final analysis. The majority of patients were younger (74.2%, 245/330). Senior patients accounted for 16.4% (54/330) of the population, and 9.4% (31/330) were older adults. All variables (the total length of stay, the length of stay following LVAD implant implantation, the percentage of patients with readmissions at 30 days, and all-cause mortality at 1 year) were similar among the three age-stratified groups. Conclusions: Despite the commonly held notion that older patients do not fare well and tend to have a higher incidence of complications resulting in a longer length of stay and higher overall mortality, we found no difference in mortality at 1 year. Well-defined, prospective studies are needed to understand the impact of age and frailty on long-term outcomes.
| Total | Younger (aged <65 years) | Senior (65-69 years) | Older adults (aged ≥ 70 years) | P value | |
| N | 330 (100%) | 245 (74.2%) | 54 (16.4%) | 31 (9.4%) | |
| Total length of stay at index hospitalization | 48.10 ± 32.65 | 59.48 ± 41.05 | 49.42 ± 33.62 | 0.088 | |
| Length of stay post-LVAD | 28.76 ± 25.34 | 31.87 ± 31.47 | 32.29 ± 31.00 | 0.630 | |
| 30-da7 readmissions | 39.18% | 33.33% | 38.71% | 0.724 | |
| All-cause mortality rates at 1 year | 12.65% | 18.52% | 22.58% | 0.223 |
Code of conduct/disclaimer available in General Terms & Conditions
{{ help_message }}
{{filter}}